Myles Bloom — presumably linked to Alistar Bloom from the previous BioShock Infinite videos, "Fact from Myth," — is hosting a new show of the same concept.
Bloom isn't investigating the floating city of Columbia this time around; rather, he is exploring the mysteries surrounding the underwater city of Rapture — particularly a mysterious woman in upstate New York who seems to have a connection to the people in the painting. I'm thinking they are Booker and Elizabeth, but what's her connection?
On a side note, you may notice that the name and theme of the show's production company has been altered. Possibly due to Columbia's cease from existence?