Coirrinne Yu works at Naughty Dog for coding animation and graphics. It's safe to say that she knows a thing or do about that Uncharted 4 teaser we saw at the end of Sony's E3 press conference. So when she was asked whether or not it was in-game, she definitely knew the answer:
@mehdicage @joshscherr @consperic In engine captured on PS4. The PS4 console is a joy to code, thank you @MarkCernyPS4 and team!
— Corrinne Yu (@Corrinne) June 10, 2014
"But wait, she never said in-game!"
Actually, she did:
@A7MADAU They are in game visuals in 3D captured on a Playstation 4.
— Corrinne Yu (@Corrinne) June 10, 2014
So there you go. The Uncharted 4 teaser was running on an in-game engine. I'm glad we avoided any Killzone 2 type scenarios here.